January 2025
Original Research
Prognostic value of C-Kit and vascular endothelial growth factor immunoreactivity for limited-stage small-cell lung cancer
Importance of c-Kit and VEGF in lung cancer
Gulen Ece Topaloglu 1, Sezgi Sahin Duyar 1, Aydin Yilmaz 1, Funda Demirag 2, Yurdanur Erdogan 1, Merter Bora Erdogdu 3, Ulku Yilmaz 1
1 Department of Pulmonology, Atatürk Chest Diseases and Thoracic Surgery Research and Education Hospital, 2 Department of Pathology, Ataturk Chest Diseases and Thoracic Surgery Research and Education Hospital, 3 Department of Biostatistics, Faculty of Medicine, Ankara University, Ankara, Turkey
DOI:10.4328/ECAM.10106 Received : 2024-12-07 Accepted : 2024-12-31 Published Online : 2024-12-31 Printed Online : 2025-01-01 Eu Clin Anal Med 2025;13(1):1-5
Aim: To evaluate vascular endothelial growth factor (VEGF) and C-Kit positivity and their prognostic value in patients with limited-stage small-cell lung cancer.
Material and Methods: This study utilized a retrospective cohort study design. We reviewed the demographic, clinical, and pathologic characteristics of 53 patients diagnosed with small-cell lung cancer between January 2005 and August 2010. We excluded patients with extensive disease, vena cava superior syndrome, and Eastern Cooperative Oncology Group performance status 3–4, as well as those who died in traffic accidents and those who underwent pneumonectomy. We used immunohistochemical analysis to determine vascular endothelial growth factor and C-Kit positivity in 34 patients, respectively.
Results: Vascular endothelial growth factor expression was detected in 61.8% of patients, and C-Kit positivity was detected in 61.7%. Although we could not determine the prognostic significance of C-Kit positivity, vascular endothelial growth factor immunoreactivity was associated with shorter overall survival (P = 0.019; log-rank test) and poor prognosis (hazard ratio, 3.671; 95% CI, 1.257–10.723; P = 0.017) in patients with limited-stage small-cell lung cancer.
Discussion: Vascular endothelial growth factor expression is an independent prognostic factor for limited-stage small-cell lung cancer.
Keywords: C-Kit, Prognosis, Small-Cell Lung Cancer, Survival Analysis, Vascular Endothelial Growth Factor
Corresponding Author: Gulen Ece Topaloglu, Department of Pulmonology, Atatürk Chest Diseases and Thoracic Surgery Research and Education Hospital, Ankara, Turkey. • E-Mail: gulen__ece@hotmail.com • P: +90 974 50 127 271 • Corresponding Author ORCID ID: https://orcid.org/0000-0002-4660-3830
Other Authors ORCID ID: Sezgi Sahin Duyar, https://orcid.org/0000-0001-5004-4077 . Aydin Yilmaz, https://orcid.org/0000-0001-6776-2454 . Funda Demirag, https://orcid.org/0000-0003-4790-8369 . Yurdanur Erdogan, https://orcid.org/0000-0002-6213-8094 . Merter Bora Erdogdu, https://orcid.org/0000-0002-5812-8600 . Ulku Yilmaz, https://orcid.org/0000-0003-1493-8385
This study was approved by the Ethics Committee of Board of Chest Diseases and Thoracic Surgery Research and Education Hospital, Ankara (Date: 2022-01-12, No: 25)
How to cite this article: Gulen Ece Topaloglu, Sezgi Sahin Duyar, Aydin Yilmaz, Funda Demirag, Yurdanur Erdogan, Merter Bora Erdogdu, Ulku Yilmaz. Prognostic value of C-Kit and vascular endothelial growth factor immunoreactivity for limited-stage small-cell lung cancer. Eu Clin Anal Med 2025;13(1):1-5
This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of the license, visit https://creativecommons.org/licenses/by-nc/4.0/
Examining the stress, depression, anxiety levels and communication skills of pet owners and non-pet owners
Psychological impact of pets
Büşra İnce, Sena Şahin, Oğuz Öz
Department of Physiotherapy, Bandirma Onyedi Eylul University, Health Services Vocational School, Balikesir, Turkey
DOI:10.4328/ECAM.10090 Received : 2024-07-31 Accepted : 2024-10-14 Published Online : 2024-12-01 Printed Online : 2025-01-01 Eu Clin Anal Med 2025;13(1):6-9
Abstract
Aim: There are studies showing that pets have a positive effect on individuals’ psychological health. The aim of this study was to investigate the stress, depression, anxiety levels and communication skills of individuals with and without pets.
Material and Methods: A total of 240 volunteers living in Balıkesir province of Turkey, aged between 18-65, with and without pets were included in the study. The participants in the research group were required to have cats, dogs and birds at home and to have taken care of pets for at least 6 months. The “Demographic Information Form” was used for demographic information, the “Communication Skills Scale (CSS)” to measure basic communication skills, the “Perceived Stress Scale (PSS)” to determine the stress level, and the “Beck Depression Inventory (BDI)” and “Beck Anxiety Inventory (BAI)” to detect depression and anxiety symptoms, respectively. SPSS 27.0 program was used in the analyses. The significance level in the study was determined as α=0.05.
Results: There was no significant difference (p>0.05) between the groups with and without pets in terms of age, gender distribution, marital status, education level, income status and the person they live with. While BDI, BAI, and ASQ were found to be significantly lower in the group with pets than in the group without pets (p<0.05), IAS was found to be higher.
Discussion: It was concluded that having a pet has positive effects on depression, anxiety, stress levels and communication skills. It is hoped that this study will shed light on future studies on animal-assisted therapy.
Keywords: Pet, Depression, Anxiety, Stress, Communication
Corresponding Author: Büşra i̇nce, Department of Physiotherapy, Bandirma Onyedi Eylul University, Health Services Vocational School, Balikesir, Turkey. • E-Mail: fztbusrakalli@gmail.com • P: +90 542 479 71 50 • Corresponding Author ORCID ID: https://orcid.org/0000-0002-7954-6289
Other Authors ORCID ID: Sena Şahin, https://orcid.org/0009-0002-4882-196X . Oğuz Öz, https://orcid.org/0009-0006-1579-3930
This study was approved by the Ethics Committee of Non-Interventional Clinical Research, Istanbul Medipol University (Date: 2024-9-26, No: 925)
How to cite this article: Büşra İnce, Sena Şahin; Oğuz Öz. Examining the stress, depression, anxiety levels and communication skills of pet owners and non-pet owners. Eu Clin Anal Med 2025;13(1):6-9
Plasma pentraxin-3 and growth differentiation factor-15 response to acute aerobic exercise ın professional road cyclists department of physiology (medicine)
Plasma pentraxın-3 ınprofessıonal roadcyclists
Alpaslan Kisinma 1, Muaz Belviranli 2
1 Department of Physiology, Başkent University, Konya Health Vocational School, 2 Department of Physiology, Faculty of Medicine, Selçuk University, Konya, Turkey
DOI:10.4328/ECAM.10105 Received : 2024-10-04 Accepted : 2024-12-17 Published Online : 2024-12-30 Printed Online : 2025-01-01 Eu Clin Anal Med 2025;13(1):10-13
Abstract
Aim: This study aimed to evaluate the concentrations of plasma pentraxin-3 (PTX-3), growth differentiation factor-15 (GDF-15), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) before and after national and international competitions, which represent physically and psychologically intense exercises for elite and young male cyclists, who are endurance athletes.
Material and Methods: Eight young male and eight elite male cyclists participated in the study, conducted during two national and international races. The first race covered 116.4 km, and the second covered 122.5 km. Blood samples were collected before the competition, immediately after the race, and 1 hour and 3 hours post-race. The levels of PTX-3, GDF-15, IL-6, and TNF-α in the samples were analyzed using the ELISA method.
Results: The PTX-3 level in elite athletes was lower 3 hours after the competition compared to 1 hour after the race (p<0.05). GDF-15 levels in elite athletes were higher 1 and 3 hours after the race compared to before and immediately after the competition but decreased 3 hours after the competition (p<0.05). In young athletes, GDF-15 levels were higher immediately after, as well as 1 and 3 hours post-race, compared to pre-competition levels (p<0.05). IL-6 levels in both young and elite athletes were higher immediately after and 1 hour post-race, compared to pre-competition levels (p<0.05). No significant changes were observed in TNF-α levels (p>0.05).In conclusion, in professional road cyclists, significant changes in GDF-15 and IL-6 levels were observed in response to competition, while PTX-3 and TNF-α levels remained unchanged.
Discussion: To determine the causes and sources of the change in these markers, more detailed molecular-level studies are needed, especially with experimental animals.
Keywords: Growth Differentiation Factor-15, Exercise, Inflammation, Pentraxin-3
Corresponding Author: Alpaslan Kisinma, Department of Physiology, Başkent University, Konya Health Vocational School, Konya, Turkey. • E-Mail: dralpaslankisinma@hotmail.com • P: +90 533 373 96 19 • Corresponding Author ORCID ID: https://orcid.org/0000-0002-7138-8431
Other Authors ORCID ID: Muaz Belviranli, https://orcid.org/0000-0002-2454-8818
This study was approved by the Ethics Committee of Non-Interventional Clinical Trials (Date: 2017-03-08, No: 2017/05)
How to cite this article: Alpaslan Kisinma, Muaz Belviranli. Plasma pentraxin-3 and growth differentiation factor-15 response to acute aerobic exercise ın professional road cyclists department of physiology (medicine). Eu Clin Anal Med 2025;13(1):10-13
Effectiveness of myofascial release technique on performance parameters and injury risk in young basketball players: A randomized controlled trial
Myofascial release technique on performance parameters and injury risk
Vedat Göken 1,2, Hasan Hilmi Muratlı 3, Gönül Acar 4
1 Department of Physiotherapy and Rehabilitation, Institute of Health Sciences, Marmara University, 2 Department of Physiotherapy, Vocational School of Health Services, Istinye University, 3 Department of Orthopaedic Surgery and Traumatology, School of Medicine, Marmara University, 4 Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Marmara University, Istanbul, Turkey
DOI:10.4328/ECAM.10107 Received : 2024-12-09 Accepted : 2024-12-28 Published Online : 2024-12-31 Printed Online : 2025-01-01 Eu Clin Anal Med 2025;13(1):14-18
Abstract
Aim: The study aimed to investigate the effects of myofascial release technique (MFR) on vertical jump, agility, balance, and injury risk related to the quality of functional movement execution in young basketball players.
Material and Methods: Sixty male athletes were randomly selected and divided into groups. Demographic information was collected from members of each group. Functional movement screen test (FMS), agility t-test, vertical jump test, and star excursion balance test (SEBT) were applied. The intervention group (n=30) received the MFR technique applied twice a week for six weeks before routine training; the control group (n=30) received no intervention. Final evaluations were conducted for both groups six weeks after the initial assessments.
Results: Sixty athletes (mean age: 11.5 ± 1.4 years; mean body weight: 44.5 ± 11.5 kg; mean height: 146 ± 12.8 cm; mean BMI: 19.71 ± 2.67 kg/m²) participated in the study. A statistically significant difference was found between the control and intervention groups in FMS total score, agility t-test, vertical jump test, and SEBT (p < 0.001). Regarding FMS parameters, a significant difference was observed (p < 0.05) in the deep squat, hurdle step, shoulder mobility, and active straight leg raise movements.
Discussion: The findings of this study indicated that implementing the MFR technique twice a week for six weeks before training was an effective approach for increasing vertical jump, dynamic balance, and agility performances in young basketball players while positively affecting the risk of injury.
Keywords: Myofascial Release Therapy, Physical Functional Performance, Youth Sports
Corresponding Author: Vedat Göken, Department of Physiotherapy, Vocational School of Health Services, Istinye University, Istanbul, Turkey. • E-Mail: vedatgoken@hotmail.com • P: +90 536 426 28 35 • Corresponding Author ORCID ID: https://orcid.org/0000-0002-0442-6098
Other Authors ORCID ID: Hasan Hilmi MURATLI, https://orcid.org/0000-0001-5677-8346 . Gönül ACAR, https://orcid.org/0000-0002-6964-6614
This study was approved by the Ethics Committee of Marmara University, Faculty of Medicine Clinical Researches (Date: 2022-08-29, No: 09.2022.977)
How to cite this article: Vedat Göken, Hasan Hilmi Muratlı, Gönül Acar. Effectiveness of myofascial release technique on performance parameters and injury risk in young basketball players: A randomized controlled trial. Eu Clin Anal Med 2025;13(1):14-18
Case Report
Left lower quadrant pain in the patient with situs inversus totalis; Acute appendicitis
Appendicitis in left lower quadrant pain
Arslan Hasan Kocamaz 1, Ömer Kişi 2, Abdulkadir Çelik 3, Abdullah Gürhan Duyan 4
1 Department of General Surgery, Kayseri State Hospital, Kayseri, 2 Department of General Surgery, School of Medicine, Necmettin Erbakan University, Konya, 3 Department of General Surgery, Gaziantep Dr. Ersin Arslan Training and Research Hospital, Gaziantep, 4 Department of General Surgery, Konya City Hospital, Konya, Turkey
DOI:10.4328/ECAM.10103 Received : 2024-09-27 Accepted : 2024-11-10 Published Online : 2024-11-20 Printed Online : 2025-01-01 Eu Clin Anal Med 2025;13(1):19-21
Abstract
One of the most common reasons for emergency service admissions is abdominal pain. One of these is acute appendicitis. Situs inversus totalis (SIT) is a rare genetic anomaly characterized by the transposition of the organs in the abdomen and thorax in a mirror image. In situs inversus totalis and intestinal malrotation, it is seen that the appendix is located on the left, as in other organs. We aimed to discuss a case diagnosed with situs inversus totalis and acute appendicitis and underwent a laparoscopic appendectomy in light of the literature. A 42-year-old male patient was admitted to the emergency department with left lower quadrant pain. Laparoscopic appendectomy was performed on the detection of situs inversus totalis and acute appendicitis as a result of physical examination and imaging. Rare clinical conditions such as appendicitis should be considered in cases with left lower quadrant pain and situs inversus totalis and should be included in the differential diagnosis. Early diagnosis is important as life-threatening complications may develop.
Keywords: Situs Inversus Totalis, Abdominal Pain, Acute Appendicitis
Corresponding Author: Arslan Hasan Kocamaz, Department of General Surgery, Kayseri State Hospital, Kayseri, Turkey. • E-Mail: md.ahkocamaz@gmail.com • P: +90 530 967 64 11 • Corresponding Author ORCID ID: https://orcid.org/0000-0002-5257-9611
Other Authors ORCID ID: Ömer Kişi, https://orcid.org/0000-0001-8606-2453 . Abdulkadir Çelik, https://orcid.org/0000-0002-5537-7791 . Abdullah Gürhan Duyan, https://orcid.org/0000-0003-2571-976X
This study was approved by the Ethics Committee of Necmettin Erbakan University for Non-Drug and Non-Medical Device Research (Date: 2024-10-18 No: 2024/5279)
How to cite this article: Arslan Hasan Kocamaz, Ömer Kişi, Abdulkadir Çelik, Abdullah Gürhan Duyan. Left lower quadrant pain in the patient with situs inversus totalis; Acute appendicitis.Eu Clin Anal Med 2025;13(1):19-21