September 2021

Comparison of simultaneously studied high sensitive cardiac troponin T and cardiac troponin I levels in patients diagnosed with acute myocardial ınfarction

Cardiac troponin levels

Gulay Aydın 1, Ebru Golcuk 1, Filiz Basınoglu 2

1 Department of Cardiology, 2 Department of Biochemistry, University of Health Sciences, Darica Farabi Training and Research Hospital, Kocaeli, Turkey

DOI:10.4328/ECAM.10031 Received : 2021-08-26 Accepted : 2021-09-16 Published Online : 2021-09-16 Printed Online : 2021-09-01

Abstract

Aim: The aim of this study was to compare simultaneously studied high sensitive cardiac troponin T (hs-cTnT) and cardiac troponin I (cTnI) level in patients diagnosed with acute myocardial infarction (AMI), undergoing an immediate invasive strategy or an early invasive strategy.

Material and Methods: A total of eighty-five consecutive patients, over eighteen years, diagnosed with non-ST segment elevation myocardial infarction (NSTEMI) and ST segment elevation myocardial infarction (STEMI), in whom hs-cTnT and cTnI, single or serial testing, simultaneously studied and who underwent an immediate invasive strategy or an early invasive strategy, were included in this study. The demographic features of the patients, hemogram, biochemical parameters, hs-cTnT and cTnI level were recorded on admission. The patients were classified into three groups; those with only hs-cTnT elevation (simultaneously cTnI is normal) and those with simultaneous hs-cTnT and cTnI elevation and those whose hs-cTnT and cTnI are simultaneously normal.

Results: There was no patient whose hs-cTnT value was normal when cTnI was elevated. In 34 (40.0%) patients hs-cTnT and cTnI levels were simultaneously elevated, in 33 (38.9%) patients only hs-cTnT level was elevated, in 18 (21.1%) patients hs-cTnT and cTnI levels were normal. 18 (21.1%) patients with normal hs-cTnT and cTnI level had STEMI. While hs-cTnT was high in 100% of NSTEMI patients, 51% had high cTnI. When the three groups were compared, the highest creatinine level (p=0.013), the lowest glomerular filtration rate (GFR) level (p=0.014), and the highest chronic kidney disease (CKD) (p=0.010) rate were observed in only hs-cTnT level elevated group. When the three groups were compared in terms of age and gender, statistically difference was not found between the three groups.

Discussion: Serial hs-cTnT measurements are required to diagnose NSTEMI especially in patients with CKD. Serial cTnI measurements are required to diagnose NSTEMI in normal population because of its low sensitivity. These situation causes delay in diagnosis and treatment. Therefore, cardiac biomarkers with high sensitivity and specificity are needed to diagnose AMI in a shorter time.

Keywords: High Sensitive Cardiac Troponin T, Cardiac Troponin I, Acute Myocardial Infarction

Corresponding Author: : Gulay Aydın, Department of Cardiology, University of Health Sciences, Darica Farabi Training and Research Hospital, Fevzicakmak Neighborhood, Dr. Zeki Acar Street. No:62, Postal Code: 41700, Darica, Kocaeli, Turkey. GSM: +90 532 169 81 46 F.: +90 262 655 21 71 E-Mail: drgulayaydin@gmail.com Corresponding Author ORCID ID: 0000-0002-3151-4448

How to cite this article: Gulay Aydın, Ebru Golcuk, Filiz Basınoglu. Article Comparison of simultaneously studied high sensitive cardiac troponin T and cardiac troponin I levels in patients diagnosed with acute myocardial ınfarction. Eu Clin Anal Med 2020; 9(3): 15-19