Role of fuziline in ameliorating cardiac damage

Abstract

Modifiable and non-modifiable factors play a role in the occurrence of cardiovascular diseases, as well as free radicals. Free radicals are caused by a decrease in the antioxidant level or an increase in the amount of oxidant in the cells. In the studies, it has been suggested that the consumption of vegetables, fruits and foods with high antioxidant content is effective in preventing many diseases, especially phenolic compounds with antioxidant effect prevent diseases. Phenolic compounds are essential compounds for living things and form an important part of antioxidants. Many drugs and antioxidants are being tested for the treatment of cardiac damage. Fuzi (Radix Aconiti Lateralis Preparata), one of these antioxidant substances, is defined as a Chinese herb. It is a derived form of Aconitum carmichaelii Debx. Scientific studies on Fuzi; hypolipidemic activity, kidney protection, cardiotonic activity, immune system improvement, anti-arrhythmia, anti-aging and antineoplastic activity, etc. made for its features. Our aim in this review is to present the cardiovascular, neuropharmacological, antidepressant, anticancer, anti-inflammatory and analgesic effects of fuzi, which has antioxidant properties.

Keywords

Limitations

This review is limited by the availability and heterogeneity of published studies related to fuziline.

Conclusion

According to the information obtained in researches on fuziline, its protective and supportive importance against CVDs, its antiinflammatory, anticancer, analgesic and antidepressant properties come to the fore. Additional research on its biochemical activity and bioactive components is needed to better understand these effects. This review can be a resource for further basic research and clinical applications on fuziline.

Declarations

Abbreviations

ANP: Atrial natriuretic peptide
AST: Aspartate aminotransferase
AWA: Aconite water-soluble alkaloid extract
CK: Creatine kinase
CK-MB: Creatine kinase myocardial band
CVD: Cardiovascular disease
HF: Heart failure
HIF-1: Hypoxia-inducible factor 1
IL-6: Interleukin 6
IL-10: Interleukin 10
ISO: Isoproterenol
LDH: Lactate dehydrogenase
NF-κB: Nuclear factor kappa B
NT-proBNP: N-terminal pro–B-type natriuretic peptide
PI3K/AKT/mTOR: Phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin
ROS: Reactive oxygen species
SFI: Shenfu injection
TGF-β: Transforming growth factor beta
TNF-α: Tumor necrosis factor alpha

References

1. Tanrıverdi B, Tetik ŞS. Aterosklerozun patofizyolojisi ve risk faktörleri. Marmara Pharm J. 2017;21:1-9.
   PubMed · Google Scholar
2. Sarrafzadegan N, Gotay C. CVD prevention in 2014: advances in the prevention of cardiovascular disease. Nat Rev Cardiol. 2015;12:71-73. doi:10.1038/nrcardio.2014.209
   Article · PubMed · Google Scholar
3. Karabulut H, Gülay MŞ. Serbest radikaller. MAKÜ Sag Bil Enst Derg. 2016;4(1):50-59.
   PubMed · Google Scholar
4. Tsutsui H, Kinugawa S, Matsushima S. Oxidative stress and heart failure. Am J Physiol Heart Circ Physiol. 2011;301(6):H2181-H2190. doi:10.1152/ajpheart.00554.2011
   Article · PubMed · Google Scholar
5. Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013;62:e147-e239. doi:10.1016/j.jacc.2013.05.019
   Article · PubMed · Google Scholar
6. Hensyl WR. Stedman’s Medical Dictionary. 25th ed. Baltimore, MD: Williams & Wilkins; 1990.
   PubMed · Google Scholar
7. Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345(19):1368-1377. doi:10.1056/nejmoa010307
   Article · PubMed · Google Scholar
8. Priscilla DH, Prince PSM. Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products, and antioxidants in experimentally induced myocardial infarction in Wistar rats. Chem Biol Interact. 2009;179:118-124. doi:10.1016/j.cbi.2008.12.012
   Article · PubMed · Google Scholar
9. Zhang K, Liu Y, Lin X, Yang J, Wu C. Assessment of reproductive toxicity and genotoxicity of Aconiti Lateralis Radix Praeparata and its processed products in male mice. J Ethnopharmacol. 2021;275:114102. doi:10.1016/j.jep.2021.114102
   Article · PubMed · Google Scholar
10. Gonçalves S, Moreira E, Grosso C, Andrade PB, Valentão P, Romano A. Phenolic profile, antioxidant activity, and enzyme inhibitory activities of extracts from aromatic plants used in Mediterranean diet. J Food Sci Technol. 2017;54(1):219-227. doi:10.1007/s13197-016-2453-z
    Article · PubMed · Google Scholar
11. Kolaç T, Gürbüz P, Yetiş G. Doğal ürünlerin fenolik içeriği ve antioksidan özellikleri. İnönü Üniv Sağ Hizmetleri MYO Derg. 2017;5(2)
    PubMed · Google Scholar
12. Rodríguez-Pérez C, Segura-Carretero A, Del Mar Contreras M. Phenolic compounds as natural and multifunctional anti-obesity agents: a review. Crit Rev Food Sci Nutr. 2019;59(8):1212-1229. doi:10.1080/10408398.2017.1399859
    Article · PubMed · Google Scholar
13. Hannan PA, Khan JA, Ullah I, Ullah S. Synergistic combinatorial antihyperlipidemic study of selected natural antioxidants: modulatory effects on lipid profile and endogenous antioxidants. Lipids Health Dis. 2016;15(1):151. doi:10.1186/s12944-016-0323-3
    Article · PubMed · Google Scholar
14. Baek SH, Cao L, Jeong JS, Kim HR, Nam JT, Lee GS. The comparison of total phenolics, total antioxidant, and anti-tyrosinase activities of Korean Sargassum. J Food Qual. 2021;2021:17454557. doi:10.1155/2021/6640789
    Article · PubMed · Google Scholar
15. Maleki SJ, Crespo JF, Cabanillas B. Anti-inflammatory effects of flavonoids. Food Chem. 2019;299:125124. doi:10.1016/j.foodchem.2019.125124
    Article · PubMed · Google Scholar
16. Pietta PG. Flavonoids as antioxidants. J Nat Prod. 2000;63(7):1035-1042. doi:10.1021/np9904509
    Article · PubMed · Google Scholar
17. Comunian TA, Ravanfar R, de Castro IA, Dando R, Favaro-Trindade CS, Abbaspourrad A. Improving oxidative stability of echium oil emulsions fabricated by microfluidics: effect of ionic gelation and phenolic compounds. Food Chem. 2017;233:125-134. doi:10.1016/j.foodchem.2017.04.085
    Article · PubMed · Google Scholar
18. Wu JJ, Guo ZZ, Zhu YF, et al. A systematic review of pharmacokinetic studies on herbal drug Fuzi: implications for Fuzi as personalized medicine. Phytomedicine. 2018;44:187-203. doi:10.1016/j.phymed.2018.03.001
    Article · PubMed · Google Scholar
19. Xiao P, Wang F, Gao F, Yan L, Chen D, Liu Y. A pharmacophylogenetic study of Aconitum L. (Ranunculaceae) from China. Acta Phytotaxon Sin. 2006;44(1):1-46. doi:10.1360/aps050046
    Article · PubMed · Google Scholar
20. Chinese Pharmacopoeia Commission. Pharmacopoeia of the People’s Republic of China. Beijing: People’s Medical Publishing House; 2010:177-178
    PubMed · Google Scholar
21. Zhou G, Tang L, Zhou X, Wang T, Kou Z, Wang Z. A review on phytochemistry and pharmacological activities of the processed lateral root of Aconitum carmichaelii Debeaux. J Ethnopharmacol. 2015;160:173-193. doi:10.1016/j.jep.2014.11.043
    Article · PubMed · Google Scholar
22. Sun J, Zhang F, Peng Y, et al. Quantitative determination of diterpenoid alkaloid fuziline by hydrophilic interaction liquid chromatography-electrospray ionization mass spectrometry and its application to pharmacokinetic study in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2013;913-914:55-60. doi:10.1016/j.jchromb.2012.11.017
    Article · PubMed · Google Scholar
23. Wang BB, Wang JL, Yuan J, et al. Composition analysis of Fuzi polysaccharides by HPLC-MS(n) and their protective effects on Schwann cells exposed to high glucose. Molecules. 2016;21(11):1496. doi:10.3390/molecules21111496
    Article · PubMed · Google Scholar
24. Farahani MS, Bahramsoltani R, Farzaei MH, Abdollahi M, Rahimi R. Plant-derived natural medicines for the management of depression: an overview of mechanisms of action. Rev Neurosci. 2015;26(3):305-321. doi:10.1515/revneuro-2014-0058
    Article · PubMed · Google Scholar
25. Nyirimigabo E, Xu Y, Li Y, Wang Y, Agyemang K, Zhang Y. A review on phytochemistry, pharmacology, and toxicology studies of Aconitum. J Pharm Pharmacol. 2015;67(1):1-19. doi:10.1111/jphp.12310
    Article · PubMed · Google Scholar
26. Ren MY, Yu QT, Shi CY, Luo JB. Anticancer activities of C18-, C19-, C20-, and bis-diterpenoid alkaloids derived from genus Aconitum. Molecules. 2017;22(2):267. doi:10.3390/molecules22020267
    Article · PubMed · Google Scholar
27. Zhao D, Shi Y, Zhu X, et al. Identification of potential biomarkers from Aconitum carmichaelii, a traditional Chinese medicine, using a metabolomic approach. Planta Med. 2018;84(6-07):434-441. doi:10.1055/s-0043-121708
    Article · PubMed · Google Scholar
28. Liu L, Li B, Zhou Y, et al. Antidepressant-like effect of Fuzi total alkaloid on ovariectomized mice. J Pharmacol Sci. 2012;120(4):280-287. doi:10.1254/jphs.12163fp
    Article · PubMed · Google Scholar
29. Wang L, Ding JY, Liu XX, Tang MH, Chao RB, Wang FP. Identification of aminoalcohol-diterpenoid alkaloids in Aconiti Lateralis Radix praeparata and study of their cardiac effects. Yao Xue Xue Bao. 2014;49(12):1699-1704.
    PubMed · Google Scholar
30. Xu X, Xie X, Zhang H, et al. Water-soluble alkaloids extracted from Aconiti Radix lateralis praeparata protect against chronic heart failure in rats via a calcium signaling pathway. Biomed Pharmacother. 2021;135:111184. doi:10.1016/j.biopha.2020.111184
    Article · PubMed · Google Scholar
31. Zhang XJ, Song L, Zhou ZG, Wang XM. Effect of Shenfu injection on gastrointestinal microcirculation in rabbits after myocardial ischemia-reperfusion injury. World J Gastroenterol. 2006;12(27):4389-4391. doi:10.3748/wjg.v12.i27.4389
    Article · PubMed · Google Scholar
32. Fan CL, Yao ZH, Ye MN, et al. Fuziline alleviates isoproterenol-induced myocardial injury by inhibiting ROS-triggered endoplasmic reticulum stress via PERK/eIF2α/ATF4/CHOP pathway. J Cell Mol Med. 2020;24(2):1332-1344. doi:10.1111/jcmm.14803
    Article · PubMed · Google Scholar
33. Storch A, Kaftan A, Burkhardt K, Schwarz J. 1-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol) is toxic to dopaminergic neuroblastoma SH-SY5Y cells via impairment of cellular energy metabolism. Brain Res. 2000;855(1):67-75. doi:10.1016/s0006-8993(99)02272-6
    Article · PubMed · Google Scholar
34. Lu CY, Ding ML, Cai SH, Xie H, Zhang W, Di LQ. Analysis of alkaloids in Aconiti Lateralis Radix Praeparata and prediction of their mechanism in the treatment of cancer. J Nanjing Univ Tradit Chin Med. 2021;37(5):720-729.
    PubMed · Google Scholar
35. Zhang Q, Chen X, Luo Y, Ren H, Qiao T. Fuzi enhances anti-tumor efficacy of radiotherapy on lung cancer. J Cancer. 2017;8(19):3945-3951. doi:10.7150/jca.22162
    Article · PubMed · Google Scholar
36. Li P, Lv B, Jiang X, et al. Identification of NF-κB inhibitors following Shenfu injection and bioactivity-integrated UPLC/Q-TOF-MS and screening for related anti-inflammatory targets in vitro and in silico. J Ethnopharmacol. 2016;194:658-667. doi:10.1016/j.jep.2016.10.052
    Article · PubMed · Google Scholar
37. Gong XH, Li Y, Li YX, et al. Development and validation of an UPLC-Q-TOF-MS method for quantification of fuziline in beagle dog after intragastric and intravenous administration. J Chromatogr Sci. 2016;54(3):405-412
    PubMed · Google Scholar

Figures

Fullscreen

Figure 1. Chemical Form of Fuziline.¹⁸

Additional Information

Publisher’s Note
Bayrakol MP remains neutral with regard to jurisdictional and institutional claims.

Rights and Permissions

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). To view a copy of the license, visit https://creativecommons.org/licenses/by-nc/4.0/

View full license details →