An overview of pulmonary manifestations in sickle cell disease

Abstract

The increased survival of patients with sickle cell disease (SCD) into adulthood leads an increased incidence of multiorgan dysfunction. The lung is one of the most common organs that may be involved in SCD. The pulmonary manifestations of SCD are the leading cause of morbidity and mortality in these patients. Although pulmonary manifestations of SCD are very common, they remain underdiagnosed by clinicians. The main pulmonary manifestations of SCD are acute chest syndrome, chronic dyspnea, asthma, sleep-disordered breathing, acute and chronic venous thromboembolic disease, pulmonary hypertension, and pulmonary fibrosis. Herein, the current knowledge of the pathophysiology, diagnosis, and treatment of pulmonary manifestations of SCD are reviewed.

Keywords

Conclusion

Pulmonary complications are common causes of death in patients with SCD. The pulmonary manifestations of SCD are difficult to manage because they result from the complicated and complex pathophysiology of SCD. Considering that pulmonary manifestations are responsible for a big proportion of mortalities in SCD patients, clinicans should be aware of acute and chronic complications of SCD.

Declarations

References

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