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January 2017

Original Article

Predictive Value of Ischemia Modified Albumin in Determining the Severity of Coronary Artery Disease

Oguzhan Toklu1, Evren Akgol2, Murat Yesil1, Fusun Ustuner3, Sedat Abusoglu4

1Department of Cardiology, İzmir Ataturk Training and Education Hospital, İzmir, 2Department of Biochemistry, Birecik State Hospital, Urfa, 3Department of Biochemistry, İzmir Ataturk Training and Education Hospital, İzmir, 4Department of Biochemistry, Selcuk University Faculty of Medicine, Konya, Turkey

DOI: 10.4328/AEMED.100


Aim: Diagnosing myocardial ischemia in patients with chest pain via non- diagnostic electrocardiograms (ECG) and cardiac markers is challenging. The objective of this study is to determine the predictive value of Ischemia Modi- fied Albumin (IMA) levels for coronary artery disease (CAD) severity in Unsta- ble Angina Pectoris (USAP) patients. Material and Method: One hundred and twenty-five patients with chest pain and non-diagnostic ECG findings were included in the study. All patients underwent coronary angiography and CAD severity was evaluated by the Gensini scoring system. Patients were divided into two groups. IMA levels were measured by spectrophotometry. Results: Mean IMA levels were significantly higher in patients than in healthy persons (0.762±0.059; 0.681±0.055 ABSU respectively; P<0.001). In the ROC analysis the cut off value of 0.718 demonstrated CAD with a sensitivity of 76% and specificity of 74%. Positive correlation was found between IMA levels and Gensini score (P < 0.001). Discussion: IMA is a strong predictor of CAD in patients with unstable angina pectoris and is positively correlated with the severity of the disease.


Ischemia Modified Albumin (IMA); Unstable Angina Pectoris (USAP); Gensini Score; Coronary Artery Disease

Corresponding Author: Evren Akgol, Department of Biochemistry, Birecik State Hospital, Urfa, Turkey.
GSM: +905057656775 F.: +90 4146524775 E-Mail: akgolevren@yahoo.com

How to cite this article: Toklu O, Akgol E, Yesil M, Ustuner F, Abusoglu S. Predictive Value of Ischemia Mo- dified Albumin in Determining the Severity of Coronary Artery Disease. J Ann Eu Med 2017;5(1): 22-6.

Autologous Conditioned Serum Treatment in the Knee Osteoarthritis

Yunus Öç1, Bekir Eray Kilinc 2, Yigit Atalay1, Hasan Basri Sezer1, Osman Tugrul Eren1

1Sisli Hamidiye Etfal Training and Research Hospital, 2Golhisar State Hospital, İstanbul, Türkiye

DOI: 10.4328/AEMED.105


Aim: Knee Osteoarthritis (OA) is a major cause of pain and disability in older adults. Of the cytokines identified in osteoarthritic joints, interleukin-1 (IL-1) appears to be of particular importance. The present study is a randomized, prospective, single-institution study to determine the effect of interleukin 1 ß receptor antagonist (IL-1ß Ra) in OA; we made this analysis by injecting sym- metrically involved knees. Material and Method: The present study comprised 33 patients (19 female, 14 male) with 66 knees with a mean age 57.6 (range 41-70 years). Patients were included in the study if they had radiologically- verified bilateral grade 2-3 OA of the knee according to Kellgren-Lawrence classification. The patients were analyzed with Visual Analogue Scale (VAS) for pain, Knee Injury and Osteoarthritis Score (KOOS), and Knee Society Score (KSS) before the first injection was administered (pre-treatment) and again one year after the last injection (post-treatment). Results: Treatment with ACS consistently showed significant decrease in VAS score (p<0.01). The patients reported a significant improvement in KOOS (subscores and total) one year after ACS treatment (p<0.01). The increase in KSS score from base- line to post-treatment one year also was significant (p<0.01). Discussion: Intra-articular injection of ACS (Orthokine) in patients with painful knee OA has an excellent safety profile and results in a strong clinical response. The data show that ACS (Orthokine) represents an effective and well-tolerated alternative to currently predominant treatments of OA.


Gonarthrosis; Osteoarthritis; Intra; Articular Injection; Cartilage; Knee Osteo- arthritis

Corresponding Author: Bekir Eray Kilinc, Golhisar State Hospital, İstanbul, Türkiye. GSM: +905306061884 E-Mail: dreraykilinc@gmail.com

How to cite this article: Toklu O, Akgol E, Yesil M, Ustuner F, Abusoglu S. Predictive Value of Ischemia Mo- dified Albumin in Determining the Severity of Coronary Artery Disease. J Ann Eu Med 2017;5(1): 22-6.

How to cite this article:

Öç Y,Kilinc BE, Atalay Y, Sezer HB, Eren OT. Autologous Conditioned Serum Treat- ment in the Knee Osteoarthritis. J Ann Eu Med 2017;5(1): 17-21.

Case Report

An Epidermal Cyst Mimicking a Pilonidal Cyst: Case Report

Yavuz Savas Koca1, İhsan Yıldız1, Mustafa Ugur2, Tugba Gürsoy Koca3

1Department of General Surgery, Suleyman Demirel University, School of Medicine, Isparta, 2Department of General Surgery, Mustafa Kemal University, School of Medicine, Hatay, 3Department of Pediactric Gastroenterology, Hepatology and Nutrition, Suleyman Demirel University, School of Medicine, Isparta, Turkey

DOI: 10.4328/AEMED.103


Epidermal cysts consist of connective tissues including skin appendages coated by epithelia and the wall which may contain keratin, sebum, or follicle. Intergluteal sulcus is the specific region of localization for pilonidal cysts. Development of epidermal cysts in this region is extremely rare. We present a 17-year-old woman with an epidermal cyst in the intergluteal region that mimicked a pilonidal cyst ab- scess. A 17-year-old woman presented to the emergency service with complaints of pain and swelling in the intergluteal region. A mass excision was performed. In the histopathological examination, the mass was reported an epidermal cyst. The possibility of an epidermal cyst should be kept in mind in the differential diagnosis of benign and malignant diseases of the perianal region.


Epidermal Cysts; Pilonidal Cyst; Epidermal Cyst

Corresponding Author: İhsan Yıldız, Department of Genaral Surgery, Suleyman Demirel University, Scholl of Medicine, 32100, Isparta, Turkey. GSM: +905052119248 F.: +90 2462113628 E-Mail: drihsanyildiz@gmail.com

How to cite this article: Koca YS, Yıldız İ, Ugur M, Koca TG. An Epidermal Cyst Mimicking a Pilonidal Cyst: Case Report. J Ann Eu Med 2017;5(1): 30-2.


Squamous Cell Carcinoma of Nasal Septum: Case Report

Özer Erdem Gür1, Nuray Ensari1, Dilek Şenel2, Dudu Gül Ceylan1, Halit Çetin Önol1 1Kulak Burun Boğaz Kliniği, 2Plastik ve Reconstruktif Cerrahi Kliniği, Antalya Eğitim ve Araştırma Hastanesi,Antalya, Türkiye

DOI: 10.4328/AEMED.101


Primary nasal septum tumours are extremely rarely seen among nasal cavity tu- mours and mostly originate from the end section of the caudal septum. Septum tumours are seen with complaints such as recurrent epistaxis, nasal obstruction, discharge, facial oedema or pain. In the examination of a patient who presented with complaints of breathing difficulties, there was seen to be a bleeding lesion of approximately 20 x 15 mm which was crusted over and raised from the mucosa, over the medial crus in the anterior and extending to the alar cartilage. Squamous cell carcinoma was reported as a result of the biopsy. The lesion was excised en bloc and the defect was reconstructed with a sublabial pedicled flap. Although local recurrence rates are high in nasal septum carcinomas, these are tumours which respond well to treatment if determined in the early stages. Treatment of nasal septum malignancies includes surgical treatment, radiotherapy or combined treatment.


Nasal Septum Tumours; Squamous Cell Carcinoma; Sublabial Pedicled Flap

Corresponding Author: Özer Erdem Gür, Meltem Mah. 2. Cadde B Blok 6/11, Antalya, Turkey. GSM: +905325996175 E-Mail: erdemkaptan@yahoo.com

How to cite this article: Gür ÖE, Ensari N, Şenel D, Ceylan DG, Önol HÇ. Squamous Cell Carcinoma of Na- sal Septum: Case Report. J Ann Eu Med 2017;5(1): 27-9.