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Original Research

The GGT / HDL ratio is positively correlated with hemoglobin A1c in the population with type II diabetes mellitus

The y-glutamyltransferase / high density lipoprotein ratio

Süheyl Uçucu 1, Talha Karabıyık 2, Dilek Gibyeli Genek 3

1 Department of Medical Biochemistry, Muğla Public Health Laboratory, Muğla, 2 Department of Medical Biochemistry, Bursa City Hospital, Bursa, 3 Department of Internal Medicine, Muğla Sıtkı Kocman University Faculty of Medicine, Muğla, Turkey

DOI:10.4328/ECAM.10035 Received : 2022-02-24 Accepted : 2022-05-09 Published Online : 2022-05-17

Abstract

Aim: Gamma-glutamyltransferase (GGT) and high density lipoprotein (HDL) have roles in fatty liver, atherosclerosis, oxidative stress, diabetes, and insulin resistance.
This study’s aim was to examine the predictive value of GGT/HDL ratio and of triglyceride/HDL ratio for patients
with type II diabetes mellitus (T2DM) and to evaluate their diagnostic efficacy.
As far as we know, this is the first study examining the utility of GGT/HDL ratio in type II diabetes mellitus, its
predictive value and its diagnostic efficacy.

Material and Methods: A total of 90 people with similar demographic characteristics, including 60 patients with
T2DM and a control group consisting of 30 individuals, were included in this study. Age, sex, fasting serum glucose, total cholesterol, triglycerides, HDL, LDL, GGT, fasting serum insulin, HbA1c, uric acid, C-reactive protein, triglycerides/HDL ratio, GGT/HDL ratio and uric acid/HDL ratio levels were evaluated within the scope of the study.

Results: A difference in TAG/HDL ratio between the patient and control groups was found (p=0.005). A significant
difference was found in GGT/HDL ratio between the patient and control groups (p=0.021).
Positive correlations were found between TAG/HDL ratio and HbA1c and between TAG/HDL ratio and glucose in
the patient and control groups (rho: 0.251, p:0.018; rho: 0.349, p< 0.001, respectively). Positive correlations were
found between GGT/HDL ratio and HbA1c and GGT/HDL ratio and glucose (rho: 0.252, p< 0.017; rho: 0.371, p<0.001,
respectively). According to the ROC analysis, the AUC results were as follows: AUC: 0.682 for triglyceride/HDL
ratio and AUC: 0.651 for GGT/HDL ratio.

Discussion: In conclusion, there were significant associations between GGT/HDL and diabetes and between
triglycerides/HDL and diabetes in type 2 diabetic patients. The GGT/HDL ratio was found to have a positive correlation with HbA1c and glucose. Both indices may have high discriminatory power to predict the patients with
T2DM (AUC of TAG/HDL: 0.682 and AUC of GGT/HDL: 0.651). However, prospective studies with more subjects are
required for validation purposes. As far as we know, this is the first study describing the usefulness of GGT/HDL
ratio in type II diabetes mellitus, its predictive value and its diagnostic efficacy.

Keywords: Type II Diabetes, Triglycerides/HDL Ratio, GGT/HDL Ratio, HbA1c, Gamma-Glutamyl Transferase (GGT)

Corresponding Author: Süheyl Uçucu, Department of Medical Biochemistry, Muğla Public Health Laboratory, Muğla, Turkey. P: +90 555 306 28 74 • E-Mail: suheyllucucu@gmail.com • Corresponding Author ORCID ID: https://orcid.org/0000-0002-6320-2457

How to cite this article: Süheyl Uçucu, Talha Karabıyık, Dilek Gibyeli Genek. The GGT / HDL ratio is positively correlated with hemoglobin A1c in the population with type II diabetes mellitus. Eu Clin Anal Med 2020; DOI:10.4328/ECAM.10035