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Original Research

Evaluation of geriatric patients with carbon monoxide intoxication presenting to the emergency department

Geriatric patients with carbon monoxide intoxication

Hüseyin Uzunosmanoğlu, Seda Dağar, Şeref Kerem Çorbacıoğlu, Yunsur Çevik

Department of Emergency Medicine, Kecioren Training and Research Hospital, Ankara, Turkey

DOI:10.4328/ECAM.10025 Received : 2020-10-21 Accepted : 2020-11-21 Published Online : 2020-12-03

Abstract

Aim: In this study, we aimed to evaluate geriatric patients admitted to the emergency department with CO intoxication with regard to their demographic and epidemiological factors, and to assess changes in their inflammatory parameters.

Material and Methods: This was a retrospective study enrolling patients aged 65 years or older with a carboxy- hemoglobin [COHb] level above 5%. The patients were grouped into 2 groups as mild to moderate/severe intox- ication groups. Demographic, epidemiological data and inflammatory parameters were evaluated. A p-value of less than p<0.05 was considered statistically significant.

Results: This study included 95 patients. The mean COHb level of the patients was 24. Among the study popula- tion, 63.2% presented with mild intoxication and 36.8% with moderate-severe intoxication. A comparison of the inflammatory parameters with respect to intoxication severity and cardiac involvement revealed a significantly lower platelet-lymphocyte ratio [p<0.001], but significantly higher [p<0.05] other parameters in patients with moderate-severe intoxication and cardiac involvement.

Discussion: In the present study, in which we aimed to investigate CO intoxication in the geriatric age group, we found that CO intoxication in elderly patients had characteristics similar to those of the general population. Also, we observed significant changes in all systemic inflammatory parameters in moderate-severe intoxication cases compared to mild intoxication cases.

Keywords: Geriatric; Carbon monoxide intoxication; Inflammation

Corresponding Author: Hüseyin Uzunosmanoğlu, Kecioren Training and Research Hospital, Department of Emergency Medicine, Ankara, Turkey. GSM: +90 5058908090 • P.: +90 312 356 90 00 • F.: +90 312 3569002 • E-Mail: huzunosmanoglu@gmail.com • Corresponding Author ORCID ID: https://orcid.org/0000-0002-4370-1283

How to cite this article: Hüseyin Uzunosmanoğlu, Seda Dağar, Şeref Kerem Çorbacıoğlu, Yunsur Çevik. Evaluation of geriatric patients with carbon monoxide ıntoxication presenting to the emergency department. Eu Clin Anal Med 2020; DOI:10.4328/ECAM.10025

 

The GGT / HDL ratio is positively correlated with hemoglobin A1c in the population with type II diabetes mellitus

The y-glutamyltransferase / high density lipoprotein ratio

Süheyl Uçucu 1, Talha Karabıyık 2, Dilek Gibyeli Genek 3

1 Department of Medical Biochemistry, Muğla Public Health Laboratory, Muğla, 2 Department of Medical Biochemistry, Bursa City Hospital, Bursa, 3 Department of Internal Medicine, Muğla Sıtkı Kocman University Faculty of Medicine, Muğla, Turkey

DOI:10.4328/ECAM.10035 Received : 2022-02-24 Accepted : 2022-05-09 Published Online : 2022-05-17

Abstract

Aim: Gamma-glutamyltransferase (GGT) and high density lipoprotein (HDL) have roles in fatty liver, atherosclerosis, oxidative stress, diabetes, and insulin resistance.
This study’s aim was to examine the predictive value of GGT/HDL ratio and of triglyceride/HDL ratio for patients
with type II diabetes mellitus (T2DM) and to evaluate their diagnostic efficacy.
As far as we know, this is the first study examining the utility of GGT/HDL ratio in type II diabetes mellitus, its
predictive value and its diagnostic efficacy.

Material and Methods: A total of 90 people with similar demographic characteristics, including 60 patients with
T2DM and a control group consisting of 30 individuals, were included in this study. Age, sex, fasting serum glucose, total cholesterol, triglycerides, HDL, LDL, GGT, fasting serum insulin, HbA1c, uric acid, C-reactive protein, triglycerides/HDL ratio, GGT/HDL ratio and uric acid/HDL ratio levels were evaluated within the scope of the study.

Results: A difference in TAG/HDL ratio between the patient and control groups was found (p=0.005). A significant
difference was found in GGT/HDL ratio between the patient and control groups (p=0.021).
Positive correlations were found between TAG/HDL ratio and HbA1c and between TAG/HDL ratio and glucose in
the patient and control groups (rho: 0.251, p:0.018; rho: 0.349, p< 0.001, respectively). Positive correlations were
found between GGT/HDL ratio and HbA1c and GGT/HDL ratio and glucose (rho: 0.252, p< 0.017; rho: 0.371, p<0.001,
respectively). According to the ROC analysis, the AUC results were as follows: AUC: 0.682 for triglyceride/HDL
ratio and AUC: 0.651 for GGT/HDL ratio.

Discussion: In conclusion, there were significant associations between GGT/HDL and diabetes and between
triglycerides/HDL and diabetes in type 2 diabetic patients. The GGT/HDL ratio was found to have a positive correlation with HbA1c and glucose. Both indices may have high discriminatory power to predict the patients with
T2DM (AUC of TAG/HDL: 0.682 and AUC of GGT/HDL: 0.651). However, prospective studies with more subjects are
required for validation purposes. As far as we know, this is the first study describing the usefulness of GGT/HDL
ratio in type II diabetes mellitus, its predictive value and its diagnostic efficacy.

Keywords: Type II Diabetes, Triglycerides/HDL Ratio, GGT/HDL Ratio, HbA1c, Gamma-Glutamyl Transferase (GGT)

Corresponding Author: Süheyl Uçucu, Department of Medical Biochemistry, Muğla Public Health Laboratory, Muğla, Turkey. P: +90 555 306 28 74 • E-Mail: suheyllucucu@gmail.com • Corresponding Author ORCID ID: https://orcid.org/0000-0002-6320-2457

How to cite this article: Süheyl Uçucu, Talha Karabıyık, Dilek Gibyeli Genek. The GGT / HDL ratio is positively correlated with hemoglobin A1c in the population with type II diabetes mellitus. Eu Clin Anal Med 2020; DOI:10.4328/ECAM.10035