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September 2022

Original Research

The GGT / HDL ratio is positively correlated with hemoglobin A1c in the population with type II diabetes mellitus

The y-glutamyltransferase / high density lipoprotein ratio

Süheyl Uçucu 1, Talha Karabıyık 2, Dilek Gibyeli Genek 3

1 Department of Medical Biochemistry, Muğla Public Health Laboratory, Muğla, 2 Department of Medical Biochemistry, Bursa City Hospital, Bursa, 3 Department of Internal Medicine, Muğla Sıtkı Kocman University Faculty of Medicine, Muğla, Turkey

DOI:10.4328/ECAM.10035 Received : 2022-02-24 Accepted : 2022-05-09 Published Online : 2022-05-17 Printed Online : 2022-09-01

Abstract

Aim: Gamma-glutamyltransferase (GGT) and high density lipoprotein (HDL) have roles in fatty liver, atherosclerosis, oxidative stress, diabetes, and insulin resistance. This study’s aim was to examine the predictive value of GGT/HDL ratio and of triglyceride/HDL ratio for patients with type II diabetes mellitus (T2DM) and to evaluate their diagnostic efficacy. As far as we know, this is the first study examining the utility of GGT/HDL ratio in type II diabetes mellitus, its predictive value and its diagnostic efficacy.

Material and Methods: A total of 90 people with similar demographic characteristics, including 60 patients with T2DM and a control group consisting of 30 individuals, were included in this study. Age, sex, fasting serum glucose, total cholesterol, triglycerides, HDL, LDL, GGT, fasting serum insulin, HbA1c, uric acid, C-reactive protein, triglycerides/HDL ratio, GGT/HDL ratio and uric acid/HDL ratio levels were evaluated within the scope of the study.

Results: A difference in TAG/HDL ratio between the patient and control groups was found (p=0.005). A significant difference was found in GGT/HDL ratio between the patient and control groups (p=0.021). Positive correlations were found between TAG/HDL ratio and HbA1c and between TAG/HDL ratio and glucose in the patient and control groups (rho: 0.251, p:0.018; rho: 0.349, p< 0.001, respectively). Positive correlations were found between GGT/HDL ratio and HbA1c and GGT/HDL ratio and glucose (rho: 0.252, p< 0.017; rho: 0.371, p<0.001, respectively). According to the ROC analysis, the AUC results were as follows: AUC: 0.682 for triglyceride/HDL ratio and AUC: 0.651 for GGT/HDL ratio.

Discussion: In conclusion, there were significant associations between GGT/HDL and diabetes and between triglycerides/HDL and diabetes in type 2 diabetic patients. The GGT/HDL ratio was found to have a positive correlation with HbA1c and glucose. Both indices may have high discriminatory power to predict the patients with T2DM (AUC of TAG/HDL: 0.682 and AUC of GGT/HDL: 0.651). However, prospective studies with more subjects are required for validation purposes. As far as we know, this is the first study describing the usefulness of GGT/HDL ratio in type II diabetes mellitus, its predictive value and its diagnostic efficacy.

Keywords: Type II Diabetes, Triglycerides/HDL Ratio, GGT/HDL Ratio, HbA1c, Gamma-Glutamyl Transferase (GGT)

Corresponding Author: Süheyl Uçucu, Department of Medical Biochemistry, Muğla Public Health Laboratory, Muğla, Turkey. P: +90 555 306 28 74 • E-Mail: suheyllucucu@gmail.com • Corresponding Author ORCID ID: https://orcid.org/0000-0002-6320-2457

How to cite this article:  Süheyl Uçucu, Talha Karabıyık, Dilek Gibyeli Genek. The GGT / HDL ratio is positively correlated with hemoglobin A1c in the population with type II diabetes mellitus. Eu Clin Anal Med 2022; 10(03):17-21

 The effect of home exercises given to school-aged children during the COVID-19 pandemic process on sports motivation

 Why children keep doing sports during the COVID-19 pandemic process?

Kayhan Söğüt 1, Elisa Calisgan 2, Betül Akyol 3, Yılmaz Yıldırım 4, Mehmet Göğremiş 2

1 Department of Physical Education and Sports, Faculty of Sport Science, Kangal Public Edication Center, Sivas, 2 Department of Physical Therapy and Rehabilitation, Faculty of Health Science, Kahramanmaras Sutcu Imam University, Kahramanmaras, 3 Department of Physical Education and Sports, Faculty of Sport Science, Inonu University, Malatya, 4 Department of Physical Education and Sports, Faculty of Sport Science, Sivas Selçuk Secondary School, Sivas, Turkey

DOI:10.4328/ECAM.10037 Received : 2022-09-12 Accepted : 2022-10-26 Published Online : 2022-10-26 Printed Online : 2022-09-01

Abstract

Aim: This study aimed to investigate the effect of home exercises given to secondary and high school students during the pandemic process on sports motivation. Material and Methods: This study was conducted on 117 (n:61 female, n:56 male) people aged 11-15 years. The children given online via the EBA home exercises program in the study were reached at Kangal Mehmet Salih Şirin, Sivas Selçuk, Sivas Durdulu, Gürün 80. Yıl Boarding District Secondary School and Kangal Koç Anatolian High School. Individuals were evaluated with Sport Motivation Scale at the pre-post exercise program.

Results: Regarding the scores between females and males, no statistically significant difference was found between the female and males in terms of age, sex, BMI, education status, medical history, career, habits, socioeconomic status and comorbidity values. In the comparative analysis, improvement in the points of all parameters in females was significantly lower than in males. There was a statistically significant difference between females and males in terms of identified regulation, which is a subscale of external stimulation. Also, the change in the level of external and identified regulation after exercises in males was statistically better than in females.

Discussion: As a result of the study, home exercises are useful for increasing sport motivation during the COVID-19 pandemic, especially in males than in females. The findings of these data can be used in models in the future.

Keywords: Exercises, School-Aged, Pandemic, Motivation, Sport

Corresponding Author: Elisa Calisgan, Department of Physical Therapy and Rehabilitation, Faculty of Health Science, Kahramanmaras Sutcu Imam University, Kahramanmaras, Posta Code:46, Turkey. E-Mail: elisa.calisgan@inonu.edu.tr • P: +90 534 246 24 71 • Corresponding Author ORCID ID: https://orcid.org/0000-0003-4710-9540

How to cite this article: Kayhan Söğüt, Elisa Calisgan, Betül Akyol, Yılmaz Yıldırım, Mehmet Göğremiş. The effect of home exercises given to school-aged children during the COVID-19 pandemic process on sports motivation. Eu Clin Anal Med 2022;10(3):22-26

 Role of intestinal barrier and dysfunction in cancer cachexia

 Intestinal barrier and cachexia

Zeynep Ergenç 1, Hasan Ergenç 1, Özlem Özkul 2, Ayşe Erdoğan Çakar 3, Fatma Behice Cinemre 4, Cemil Bilir 2

1 Department of Internal Medicine, Ayancık Government Hospital, Sinop, 2 Department of Medical Oncology, Faculty of Medicine, Sakarya University, Training and Research Hospital, Sakarya, 3 Department of Chemistry, Faculty of Medicine, Yıldız Technical University, Istanbul, 4 Department of Biochemistry, Faculty of Medicine, Sakarya University, Training and Research Hospital, Sakarya, Turkey

DOI: 10.4328/ECAM.10045 Received : 2022-09-27 Accepted : 2022-10-11 Published Online : 2022-10-11 Printed Online : 2022-09-01

Abstract

Aim: In this study, we aimed to determine whether weight loss could be estimated by measuring small intestine function in patients who will start chemotherapy.

Material and Methods: Serum TRAF 6, citrulline and TNF α, hs-CRP, transferrin, ceruloplasmin levels were compared with controls and tumor stages.

Results: In patients with weight loss after chemotherapy, a statistically significant correlation was found with basal serum citrulline levels.

Discussion: Patients who had weight loss according to the pre-chemo stage had lower levels of serum citrulline compared to patients who did not lose weight.

Keywords: Cachexia, Cancer, Citrulline 

Corresponding Author:  Hasan Ergenc, Department of Internal Medicine, Ayancık Government Hospital, Cevizli Mah. Nakliyeciler Sok. No:1, Ayancik, 57400, Sinop, Turkey. E-Mail: dr.hasanergenc@hotmail.com • P: +90 368 613 10 27 • Corresponding Author ORCID ID: https://orcid.org/0000-0003-0519-0264 

How to cite this article: Zeynep Ergenç, Hasan Ergenç, Özlem Özkul, Ayşe Erdoğan Çakar, Fatma Behice Cinemre, Cemil Bilir. Role of intestinal barrier and dysfunction in cancer cachexia. Eu Clin Anal Med 2022; 10(3):27-30 

Review Article

 Role of fuziline in ameliorating cardiac damage

 Cardiac damage and fuziline

Yasemin Hacanlı, Ezhar Korkmaz Ersöz

Department of Cardiovascular Surgery, Faculty of Medicine, Harran University, Şanlıurfa, Turkey

DOI: 10.4328/ECAM.10041 Received : 2022-09-22 Accepted : 2022-10-11 Published Online : 2022-10-11 Printed Online : 2022-09-01

Abstract

Modifiable and non-modifiable factors play a role in the occurrence of cardiovascular diseases, as well as free radicals. Free radicals are caused by a decrease in the antioxidant level or an increase in the amount of oxidant in the cells. In the studies, it has been suggested that the consumption of vegetables, fruits and foods with high antioxidant content is effective in preventing many diseases, especially phenolic compounds with antioxidant effect prevent diseases. Phenolic compounds are essential compounds for living things and form an important
part of antioxidants. Many drugs and antioxidants are being tested for the treatment of cardiac damage. Fuzi (Radix Aconiti Lateralis Preparata), one of these antioxidant substances, is defined as a Chinese herb. It is a derived form of Aconitum carmichaelii Debx. Scientific studies on Fuzi; hypolipidemic activity, kidney protection, cardiotonic activity, immune system improvement, anti-arrhythmia, anti-aging and antineoplastic activity, etc. made for its features. Our aim in this review is to present the cardiovascular, neuropharmacological, antidepressant, anticancer, anti-inflammatory and analgesic effects of fuzi, which has antioxidant properties.

Keywords: Fuziline, Dobutamine, Antioxidant, Cardiovascular Diseases, Myocardial Damage 

Corresponding Author: Yasemin Hacanli, Department of Cardiovascular Surgery, Faculty of Medicine, Harran University, Şanlıurfa, Turkey.
E-Mail: yaseminhacan@hotmail.com • P: +90 506 700 27 00 • Corresponding Author ORCID ID: https://orcid.org/0000-0002-4427-8149 

How to cite this article: Yasemin Hacanlı, Ezhar Korkmaz Ersöz. Role of fuziline in ameliorating cardiac damage. Eu Clin Anal Med 2022; 10(3):31-33

 DOX and induced cardiotoxicity

 DOX’s damage

Ezhar Korkmaz Ersöz, Yasemin Hacanlı

Department of Cardiovascular Surgery, Faculty of Medicine, Harran University, Sanliurfa, Turkey

DOI: 10.4328/ECAM.10044 Received : 2022-09-23 Accepted : 2022-10-11 Published Online : 2022-10-11 Printed Online : 2022-09-01

Abstract

Cancer, one of the most important and deadly diseases of our age, is very difficult to treat. The toxic effects of the drugs used affect the antineoplastic treatment. Anthracyclines are substances that have been proven to be beneficial in cancer chemotherapy in research on microbial products. Doxorubicin is one of the chemotherapeutic agents used in cancer treatment. A broad-spectrum anthracycline is known to have beneficial effects such as antibiotics, as well as adverse effects such as cardiac damage. Doxorubicin causes reactive oxygen radicals in the cell. Today, new natural antioxidant sources are of great importance because of the importance of using antioxidant molecules in the treatment of diseases caused by free radicals. Therefore, it has been shown that the use of antioxidants may be protective against oxidative stress caused by doxorubicin and other cytotoxic drugs. Due to the antioxidant properties of Pistacia vera L. (P. v. L.), which has a high phenolic content, it has been shown in various studies that it is beneficial in anti-inflammatory activity, glycemic control and protection of endothelial function and prevents low oxidation

Keywords: Cancer, DOX, Cardiotoxicity, Oxidative Stress, Antioxidant 

Corresponding Author: Ezhar Korkmaz Ersöz, Department of Cardiovascular Surgery, Faculty of Medicine, Harran University, Şanlıurfa, Turkey. E-Mail: ezharkorkmaz@hotmail.com • P: +90 505 707 61 90 • Corresponding Author ORCID ID: 0000-0002-7531-4958 

How to cite this article: Ezhar Korkmaz Ersöz, Yasemin Hacanlı. DOX and induced cardiotoxicity. Eu Clin Anal Med 2022; 10(3):34-37